Published Papers

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Publications using CTB materials

Gene signature of the post-Chernobyl papillary thyroid cancer
Daria Handkiewicz-Junak, Michal Swierniak, Dagmara Rusinek, Małgorzata Oczko-Wojciechowska, Genevieve Dom, Carine Maenhaut, Kristian Unger, Vincent Detours, Tetiana Bogdanova, Geraldine Thomas, Ilya Likhtarov, Roman Jaksik, Malgorzata Kowalska, Ewa Chmielik, Michal Jarzab, Andrzej Swierniak, Barbara Jarzab
Eur J Nucl Med Mol Imaging. 2016; 43: 1267–1277. Published online 2016 Jan 26. doi: 10.1007/s00259-015-3303-3

Genomic copy number analysis of Chernobyl papillary thyroid carcinoma in the Ukrainian–American Cohort
Martin Selmansberger, Herbert Braselmann, Julia Hess, Tetiana Bogdanova, Michael Abend, Mykola Tronko, Alina Brenner, Horst Zitzelsberger, Kristian Unger
Carcinogenesis. 2015 Nov; 36(11): 1381–1387. Published online 2015 Aug 29. doi: 10.1093/carcin/bgv119 

Dose-dependent expression of CLIP2 in post-Chernobyl papillary thyroid carcinomas
Martin Selmansberger, Jan Christian Kaiser, Julia Hess, Denise Güthlin, I. Likhtarev, Victor Shpak, Mykola Tronko, Alina Brenner, Michael Abend, Maria Blettner, Kristian Unger, Peter Jacob, Horst Zitzelsberger
Carcinogenesis. 2015 Jul; 36(7): 748–756. Published online 2015 May 28. doi: 10.1093/carcin/bgv043 

ETV6-NTRK3 is a common chromosomal rearrangement in radiation-associated thyroid cancer
Rebecca J. Leeman-Neill, Lindsey Kelly, Pengyuan Liu, Alina V. Brenner, Mark P. Little, Tetiana I. Bogdanova, Viktoria Evdokimova, Maureen Hatch, Liudmyla Y. Zurnadzy, Marina N. Nikiforova, Ning J. Yue, Miao Zhang, Kiyohiko Mabuchi, Mykola D. Tronko, Yuri E. Nikiforov
Cancer. Author manuscript; available in PMC 2015 Mar 15.
Published in final edited form as: Cancer. 2014 Mar 15; 120(6): 799–807. Published online 2013 Dec 10. doi: 10.1002/cncr.28484 

Identification of kinase fusion oncogenes in post-Chernobyl radiation-induced thyroid cancers
Julio C. Ricarte-Filho, Sheng Li, Maria E.R. Garcia-Rendueles, Cristina Montero-Conde, Francesca Voza, Jeffrey A. Knauf, Adriana Heguy, Agnes Viale, Tetyana Bogdanova, Geraldine A. Thomas, Christopher E. Mason, James A. Fagin
J Clin Invest. 2013 November 1; 123(11): 4935–4944. Published online 2013 October 25. doi: 10.1172/JCI69766

Iodine-131 dose-dependent gene expression: alterations in both normal and tumour thyroid tissues of post-Chernobyl thyroid cancers.
Abend M, Pfeiffer RM, Ruf C, Hatch M, Bogdanova TI, Tronko MD, Hartmann J, Meineke V, Mabuchi K, Brenner AV.
Br J Cancer. 2013 Oct 15;109(8):2286-94. doi: 10.1038/bjc.2013.574. Epub 2013 Sep 17

A gene expression signature distinguishes normal tissues of sporadic and radiation-induced papillary thyroid carcinomas
G Dom, M Tarabichi, K Unger, G Thomas, M Oczko-Wojciechowska, T Bogdanova, B Jarzab, J E Dumont, V Detours, C Maenhaut
Br J Cancer. 2012 September 4; 107(6): 994–1000. Published online 2012 July 24. doi: 10.1038/bjc.2012.302

RET/PTC and PAX8/PPARγ chromosomal rearrangements in post-Chernobyl thyroid cancer and their association with iodine-131 radiation dose and other characteristics.
Leeman-Neill RJ, Brenner AV, Little MP, Bogdanova TI, Hatch M, Zurnadzy LY, Mabuchi K, Tronko MD, Nikiforov YE.
Cancer. 2013 May 15;119(10):1792-9. doi: 10.1002/cncr.27893. Epub 2013 Feb 21.

Iodine-131 dose dependent gene expression in thyroid cancers and corresponding normal tissues following the Chernobyl accident.
Abend M, Pfeiffer RM, Ruf C, Hatch M, Bogdanova TI, Tronko MD, Riecke A, Hartmann J, Meineke V, Boukheris H, Sigurdson AJ, Mabuchi K, Brenner AV.
PLoS One. 2012;7(7):e39103

A gene expression signature distinguishes normal tissues of sporadic and radiation-induced papillary thyroid carcinomas.
Dom G, Tarabichi M, Unger K, Thomas G, Oczko-Wojciechowska M, Bogdanova T, Jarzab B, Dumont JE, Detours V, Maenhaut C.
Br J Cancer. 2012 Sep 4;107(6):994-1000

The Chernobyl Tissue Bank: integrating research on radiation-induced thyroid cancer.
Thomas GA.
J Radiol Prot. 2012 Mar;32(1):N77-80

Thyroid cancer in Ukraine after the Chernobyl accident (in the framework of the Ukraine-US Thyroid Project).
Tronko M, Mabuchi K, Bogdanova T, Hatch M, Likhtarev I, Bouville A, Oliynik V, McConnell R, Shpak V, Zablotska L, Tereshchenko V, Brenner A, Zamotayeva G.
J Radiol Prot. 2012 Mar;32(1):N65-9.

Gain of chromosome band 7q11 in papillary thyroid carcinomas of young patients is associated with exposure to low-dose irradiation.
Hess J, Thomas G, Braselmann H, Bauer V, Bogdanova T, Wienberg J, Zitzelsberger H, Unger K.
Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9595-600.

I-131 dose response for incident thyroid cancers in Ukraine related to the Chornobyl accident.
Brenner AV, Tronko MD, Hatch M, Bogdanova TI, Oliynik VA, Lubin JH, Zablotska LB, Tereschenko VP, McConnell RJ, Zamotaeva GA, O'Kane P, Bouville AC, Chaykovskaya LV, Greenebaum E, Paster IP, Shpak VM, Ron E.
Environ Health Perspect. 2011 Jul;119(7):933-9

Gene expression profiles for radiation-induced thyroid cancer.
Maenhaut C, Detours V, Dom G, Handkiewicz-Junak D, Oczko-Wojciechowska M, Jarzab B.
Clin Oncol (R Coll Radiol). 2011 May;23(4):282-8

What Have We Learnt From Chernobyl? What Have We Still To Learn?
Thomas GA, Tronko MD, Tsyb AF, Tuttle RM
Clin Oncol (R Coll Radiol). 2011 May;23(4):229-33 Feb 23. [Epub ahead of print]

The Chernobyl Accident and its Consequences.
Saenko V, Ivanov V, Tsyb A, Bogdanova T, Tronko M, Demidchik Y, Yamashita S.
Clin Oncol (R Coll Radiol). 2011 May;23(4):234-43. Epub 2011 Feb 22

Clinical Presentation and Clinical Outcomes in Chernobyl-related Paediatric Thyroid Cancers: What Do We Know Now? What Can We Expect in the Future?
Tuttle RM, Vaisman F, Tronko MD.
Clin Oncol (R Coll Radiol). 2011 May;23(4):268-75. Epub 2011 Feb 15. 

The Chernobyl Thyroid Cancer Experience: Pathology
Livolsi VA, Abrosimov AA, Bogdanova T, Fadda G, Hunt JL, Ito M, Rosai J, Thomas GA, Williams ED. 
Clin Oncol (R Coll Radiol). 2011 May;23(4):261-7. Epub 2011 Feb 18. 

Integrating Research on Thyroid Cancer after Chernobyl-The Chernobyl Tissue Bank
Thomas GA, Bethel JA, Galpine A, Mathieson W, Krznaric M, Unger K. 
Clin Oncol (R Coll Radiol). 2011 May;23(4):276-81. Epub 2011 Feb 22 

DNA Copy Number Alterations in Radiation-induced Thyroid Cancer
Zitzelsberger H, Unger K
Clin Oncol (R Coll Radiol). 2011 May;23(4):289-96

Gene Expression Profiles for Radiation-induced Thyroid Cancer
Maenhaut C, Detours V, Dom G, Handkiewicz-Junak D, Oczko-Wojciechowska M, Jarzab  B
Clin Oncol (R Coll Radiol). 2011 May;23(4):282-8. Epub 2011 Mar 15

A 25 Year Retrospective Review of the Psychological Consequences of the Chernobyl Accident
Bromet EJ, Havenaar JM, Guey LT.
Clin Oncol (R Coll Radiol). 2011 Feb 15. [Epub ahead of print]

Morphologic Characteristics of Chernobyl-Related Childhood Papillary Thyroid Carcinomas Are Independent of Radiation Exposure But Vary with Iodine Intake
E. Dillwyn Williams, Alexander Abrosimov, Tatiana Bogdanova, Evgeny P. Demidchik, Masahiro Ito, Virginia LiVolsi, Evgeny Lushnikov, Juan Rosai, Mikola D. Tronko, Anatoly F. Tsyb, Sarah L. Vowler, Geraldine A. Thomas (2008).
Thyroid. 2008 Aug; 18(8): 847-52.

Human Thyroid Tumor Cell Lines Derived from Different Tumor Types Present a Common Dedifferentiated Phenotype
Wilma C.G. van Staveren, David Weiss Solı´s, Laurent Delys, Laurence Duprez, Guy Andry, Brigitte Franc, Gerry Thomas,  Frederick Libert, Jacques E. Dumont, Vincent Detours, and Carine Maenhaut (2007). 
Cancer Res 2007; 67: (17). September 1, 2007

Genome wide gene expression profiling suggests distinct radiation susceptibilities in sporadic and post Chernobyl papillary thyroid cancers
Detours V, Delys L. Liebert F, Weiss Solis D, Bogdanova T, Dumont JE, Franc B, Thomas G, Maenhaut C (2007) 
B J Cancer 97: 818 - 825 

Gene expression and the biological phenotype of papillary thyroid carcinomas
Delys L,  Detours V, Franc B, Thomas G, Bogdanova T, Tronko M, Libert F, Dumont JE, and Maenhaut C (2007)
Oncogene  July 9  1-10 [Epub] 

Thyroid Cancer in Russia After the Chernobyl Accident eds
A.Yu Abrosimov, EF Lushnikov, EM Parshkov, VA Saenko, AF Tsyb, S Yamashita
Moscow Meditsyna 2006 ISBN 5-225-03960-X 

Chernobyl Beyond 20 years and thyroid cancer
S Yamashita (2006)
Hot Thyroidology, published online August, No 2, 2006 http://www.hotthyroidology.com/editorial_158.html

Cancer Consequences of the Chernobyl Accident
Cardis E, Howe G, Ron E, Bebeshko V, Bogdanova T, Bouville A, Carr Z, Chumak V, Davis S, Demidchik Yu, Drozdovitch V, Gentner N, Gudzenko N, Hatch M, Ivanov V, Jacob P, Kapitonova E, Kenigsberg Y, Kesminiene A, Kopecky KJ, Kryuchkov V, Loos A, Pinchera A, Reiners C, Repacholi M, Shibata Y, Shore RE, Thomas G, Tirmarche M, Yamashita S, Zvonova I (2006)
J Radiological Protection 26: 127-140 

RET rearrangements in post-Chernobyl papillary thyroid carcinomas with a short latency analysed by interphase FISH
Unger K, Zurnadzhy L, Walch A, Mall M, Bogdanova TI, Braselmann H, Hieber L, Tronko N, Hutzler P, Jeremiah S, Thomas G, Zitzelsberger H. (2006)
B J Cancer 94: 1472-1477

TP53 codon 72 polymorphism in radiation-associated human papillary thyroid cancer
Rogounovitch TI, Saenko VA, Ashizawa K, Sedliarou IA, Namba H, Abrosimov AY, Lushnikov EF, Roumiantsev PO, Konova MV, Petoukhova NS, Tchebotareva IV, Ivanov VK, Chekin SY, Bogdanova TI, Tronko MD, Tsyb AF, Thomas GA, Yamashita S. (2006)
Oncol Rep. 2006 15:949-56

Absence of a specific radiation signature in post-Chernobyl thyroid cancer
Detours V, Watte S, Venet D, Mircescu H, Burniat A, Hutsebaut N, Bogdanova T, Tronko MD, Dumont JE, Franc F, Thomas GA, Maenhaut C (2005)
Br J Cancer 92: 1545-1552

Frequency of BRAF T1794A mutation in thyroid papillary carcinoma relates to age to patient at diagnosis and not to radiation exposure.
Powell HG, Jeremiah J, Morishita M, Bethel J, Bogdanova T, Tronko M, Thomas GA (2005)
J Pathol 205: 558-564 

Investigation of loss of heterozygosity and SNP frequencies in the ret gene in papillary thyroid carcinoma
Stephens LA, Powell NG, Grubb J, Jeremiah SJ, Bethel JA, Demidchik EP, Bogdanova TI, Tronko MD, Thomas GA   (2005) 
Thyroid 15: 100-104 

Thyroid Carcinoma after Chernobyl
Williams ED,  Abrosimov A, Bogdanova TI, Demidchik EP, LiVolsi V, Lushnikov E, Rosai J, Sidorov Yu, Tronko MD, Tsyb AF, Vowler S, Thomas GA (2004)
Latent Period, Morphology and Aggressivity.  B J Cancer 90: 2219-2224

Heterogeneity in the distribution of RET/PTC rearrangements within individual post-Chernobyl papillary thyroid carcinomas
Unger K, Zitzelsberger H, Santoro M, Salvatore G, Bogdanova TI, Braselmann H, Zurnadzhy L, Tronko MD, Hutzler P, Thomas GA (2004)
JCEM 89: 4272-4279

Low Frequency of BRAFT1796Amutations in childhood thyroid carcinomas
Kumagai A, Namba H, Saenko V, Ashizawa K, Ohtsuru A, Ito M, Ishikawa N, Sugino K, Ito K, Jeremiah S, Thomas GA, Bogdanova TI, Tronko MD, Nagayasu T, Shibata Y, Yamashita S (2004)
JCEM 89: 4280-4284. 

BRAF mutations are not a major event in post- Chernobyl Thyroid Carcinomas
Lima J, Trovisco V, Soares S, Maximo V, Maghales J, Salvatore G, Santoro M, Bogdanova T, Tronko, M, Abrosimov A, Jeremiah S, Thomas G, Williams D, Sobrinho-Simoes M (2004)
JCEM 89: 4267-4271

Solid cancers following therapeutic radiation – can we predict which patients are most at risk?
Thomas GA (2004)
Clin Oncol 16: 429-434

Chromosomal imbalances in post Chernobyl thyroid Tumours
Richter H, Braselman H, Hieber L, Thomas GA, Bogdanova TI, Zitzelsberger H (2004) 
Thyroid 14 :1061-1064

Single nucleotide polymorphism analysis in the human phosphatase PTPrj gene using matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry.
Powell NG, Dudley E, Morishita M, Bogdanova TI, Tronko MD, Thomas GA(2004)
Rapid Communications in Mass Spectroscopy 18: 2249-2254 

Mitochondrial DNA mutation in post Chernobyl Thyroid Carcinoma
Lima J, Maximo V, Soares S, Williams D, Bogdanova T, Thomas GA, Sobrinho-Simoes M (2003)
Carcinogenesis 24: 1155.

The Chernobyl Tissue Bank – Integrating International Research on Thyroid Cancer.  In Radiation and Humankind
Thomas GA(2003)
Proceedings of the First Nagasaki Symposium of International Consortium for Medical Care of Hibakusha and Radiation Life Science, Nagasaki, Japan.  International Congress Series 1258,  Elsevier BV, Holland pp21-30