The project is overseen by a Steering Committee, which is comprised of representatives from each of the funding bodies and the Eastern European governments involved. It is not the aim of the project to restrict access to material - but to regulate access in such a way that the maximum amount of information can be gathered, which could lead to better patient care and assessment of risk from radiation exposure to a young population in the future.
All applications for use of the bank are referred to an independent External Review Panel, which comprises experts nominated by the organisations which sponsor the project - the European Commission (EC), the National Cancer Institute of the USA (NCI), and Sasakawa Memorial Health Foundation of Japan (SMHF) - and the governments of the participating Eastern European countries (Ukraine and Russia).
Each sample of nucleic acid or serum will be identified by
a CTB sample number and accompanied by a minimum data set
comprising the following information:
- date of birth
- date of operation
- oblast of residence
- International Pathology Review Panel diagnosis.
Further more detailed information may be available; the justification
for a request for more information than is provided in the
minimum data set should be set out in the application.
Applications to access materials and data from the CTB must
be submitted on-line. If problems are encountered with the
on-line application, applicants should contact the secretariat
to request an alternative method of submitting an application.
Applications received by the Secretariat will be
1. registered and given a number
2. acknowledged and an estimated decision date provided
3. copied to the members of the External Review Panel (ERP)
Applications are usually received and acknowledged by email
by the CTB secretariat.
An overview of the application review procedure is provided
in the flow diagram below. Details of the procedure and of
the criteria on which an application will be evaluated are
shown in the Fact Sheet.
Schema for review of applications
CTB Portal: http://cisbic.bioinformatics.ic.ac.uk/ctb/html_ctb_public
Where possible, material for a given project will be provided
in one batch, in some cases provision may have to be made
over a period of time. The distribution of materials to approved
projects will be authorised subject to:
1. receipt of the agreement by the Principal Investigator
to conform to the conditions set out in the application form
2. modification of the number and size of samples required
dependent on the availability of the material
Any project requiring more clinical information than the minimum
data set must state this clearly in the application and state
if this is an essential component of the application. Any
such project will normally be carried out as a collaboration
with the NIS institute involved and where appropriate, approval
of the relevant Ethical Committee must be sought.